Na+ currents (SCN5A) were not affected by apamin (from -261 to -268 pA/pF, P = NS), but were reduced by flecainide to -57 pA/pF (p = 0.018).
WHAT IS ICAL CARDIOLOGY PATCH
Whole-cell patch clamp techniques were used to determine ionic current densities before and after apamin administration.Ĭa2+ currents (CACNA1c+CACNB2b) were not affected by apamin (500 nM) (data are presented as median (from -16 to -17 pA/pF, P = NS), but were reduced by nifedipine to -1.6 pA/pF (p = 0.008). We studied human embryonic kidney (HEK) 293 cells that expressed human voltage-gated Na+, K+ and Ca2+ currents and isolated rabbit ventricular myocytes. To test the hypothesis that apamin does not inhibit any major cardiac ion currents. However, the specificity of apamin in cardiac tissues remains unclear.
4 Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.Īpamin is commonly used as a small-conductance Ca2+-activated K+ (SK) current inhibitor.3 Cardiovascular Research Laboratory, Departments of Medicine (Cardiology) and Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.2 Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America Department of Molecular Pathogenesis, Division of Pathophysiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.1 Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America Department of Integrated Diagnostic & Therapeutics, National Taiwan University, Taipei, Taiwan.
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